Endothelial Dysfunction in Mexican Obese Children, is there A Role of the Gut Microbiota?

Endothelial dysfunction is a predisposing factor for atherosclerosis and other cardiovascular diseases; and at the same time, endothelial dysfunction is associated to obesity. The prevalence of endothelial dysfunction, atherosclerosis and obesity is quite high among Mexican children; on the other hand, gut microbiota has been associated to obesity in the same population. Atherosclerosis is associated to gut microbiota in humans, and this association raise the possibility that endothelial dysfunction is also related with the gut microbiota in obese population. This review addresses the current knowledge of association of endothelial dysfunction, with obesity and atherosclerosis; however, there are no reports of association of endothelial dysfunction with gut microbiota through the measurement of adhesion molecules like ICAM-1, VCAM-1, and selectins.